Local Hemodynamic Changes in Hypertension

Hemodynamic changes in hypertension.

DESPITE a vast amount of work devoted to the subject the nature of the fundamental hemodynamic changes in chronic, human hypertension is poorly understood. In this necessarily brief discussion the main outlines of the problem will be sketched in emphasizing the respective roles of the heart, large arteries and resistance vessels. Other factors such as the sympathetic nervous system, the barorec...

Local hemodynamic changes in hypertension: insights for therapeutic preservation of target organs.

As a result of antihypertensive therapy, there has been a remarkable decrease in morbidity and mortality from such cardiovascular endpoints as stroke, coronary heart disease, and major hypertensive emergencies. In contrast, there has been no relenting in the increasing prevalence of cardiac failure and end-stage renal disease (ESRD) associated with hypertensive cardiovascular disease. Recent ex...

Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes.

BACKGROUND AND PURPOSE Rupture of cerebral aneurysm (CA) is the major cause of subarachnoid hemorrhage. Molecular mechanisms of this disease, however, remain unknown. To make possible genetic analysis of CA formation with genetically altered mice, we have successfully established a mouse model of saccular CA that recapitulates the essential features of human saccular CA. METHODS In C57black/6...

Hemodynamic Patterns in Essential Hypertension.

Hemodynamic changes in the prefrontal cortex during working memory in essential hypertension.

Behavioral performance and hemodynamic changes in the prefrontal cortex (PFC) represent cerebrovascular reserve and may indicate functional deficits related to essential hypertension. Fifteen stage 1 hypertensive and normotensive males (19-55 years) were compared on four tests of working memory (digit span and auditory consonant trigrams), and accompanying hemodynamic changes measured by functi...